Chemistry data
- Class
- synthetic heptapeptide derived from tuftsin
- Molecular weight
- 751.9 g/mol
- Sequence
- Thr-Lys-Pro-Arg-Pro-Gly-Pro
- Half-life
- short in plasma (minutes); intranasal delivery improves CNS access
- Routes
- intranasal · subcutaneous
- Studied doses
- intranasal 0.15–0.3 mg/day
Limitless Life Nootropics — Selank
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What if a blueprint for calmer stress responses was already sitting in your immune system? Selank is a synthetic heptapeptide modeled on tuftsin, a naturally occurring immune peptide. Research suggests it may modulate stress response and immune activity alike, with clinical work pointing to anxiety reduction. Ahead: where it came from, how researchers think it works, and what clinical studies found.
Limitless Life Nootropics — Selank
Compound15Affiliate link — we may earn a commission at no extra cost to you. Research compounds are for laboratory use only.
Regulatory Status
- United States
- Research use only
- European Union
- Research use only
- United Kingdom
- Research use only
What is this compound?
Selank begins with a molecule your body already knows: tuftsin, a naturally occurring peptide involved in immune function. Researchers built a synthetic analog — the seven-amino-acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro — designed to enhance stress response while influencing immune functions. That dual pedigree is exactly why its research profile looks so distinctive.
How it works
Three threads run through Selank research. The first is enzymatic: studies suggest it may inhibit enkephalinase, the enzyme that breaks down endogenous opioid peptides, potentially extending the body's own comfort-signaling molecules PMID: 21833148 . The second is immunological: Selank has been observed to modulate pro-inflammatory cytokines such as IL-6 and TNF-alpha, placing it squarely in neuroinflammation research PMID: 21493795 . The third ties directly to anxiety — interaction with the GABAergic system is believed to drive its anxiolytic effects PMID: 21833148 . A compound speaking to both immune and neural circuits raises an obvious question: what does that look like clinically?
- Enkephalinase inhibition modulating endogenous opioid peptides
- IL-6 and TNF-alpha cytokine modulation affecting neuroinflammation
- GABAergic system interaction promoting anxiolytic effects
Research Findings
Clinical studies suggest Selank may reduce anxiety, especially among individuals experiencing generalized anxiety disorder PMID: 21833148 — the anchor for most interest in the compound. Preliminary evidence points to immune modulation as well, extending its reach into stress-related immune responses PMID: 21493795 . Preclinical findings add a third possibility: enhanced cognitive functioning PMID: 21833148 , a combination that would distinguish it from sedating alternatives. The strongest thread leads straight to the dosing questions researchers tackled first.
- anxiety-reduction clinical
- immune-modulation preclinical
- cognitive-enhancement preclinical
Dosage Context Explained
Intranasal dosing in clinical studies of anxiety symptoms has ranged from 0.15 to 0.3 mg per day PMID: 21493795 . These figures describe research protocols, not validated treatment guidance — but they give a concrete sense of scale, and they lead naturally into the tolerability question.
-
- Administration Routes
- intranasal
- Range
- 0.15–0.3 mg/day
clinical studies for generalized anxiety disorder
Reconstitution Calculator
Determine exactly how much bacteriostatic water to add and how many units to draw for your target dose.
Side Effects: Research Context
Reported experience with Selank suggests it is generally well tolerated. The documented complaints are modest: nasal irritation with spray delivery, transient drowsiness at higher doses, and occasional mild sedation. Larger studies remain the missing piece of the safety picture — and they head the agenda for the compound's next research phase.
- nasal irritation (with spray)
- transient drowsiness
- mild sedation at higher doses
Where to source
Research use only| Supplier | Commission | Use coupon | |
|---|---|---|---|
| Limitless Life Nootropics | 15% | Compound1515% off | Source research-grade Selank |
| Ascension Peptides | 20% + 10% lifetime | COMPOUNDGU10% off | Source research-grade Selank |
Affiliate link — we may earn a commission at no extra cost to you. Research compounds are for laboratory use only.
Limitless Life Nootropics — Selank
Compound15Affiliate link — we may earn a commission at no extra cost to you. Research compounds are for laboratory use only.
Frequently Asked Questions
Frequently Asked Questions
-
Selank is primarily studied for its potential in anxiety reduction and immune modulation, showing promising results in clinical settings.
-
Selank can be administered intranasally or subcutaneously, with intranasal delivery improving central nervous system access.
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Reported side effects include nasal irritation and drowsiness, especially at higher doses.
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Research suggests that Selank may effectively reduce anxiety and modulate immune responses, but more studies are needed to confirm its long-term safety and efficacy.
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